Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing
نویسندگان
چکیده
منابع مشابه
Forkhead Transcription Factors Establish Origin Timing and Long-Range Clustering in S. cerevisiae
The replication of eukaryotic chromosomes is organized temporally and spatially within the nucleus through epigenetic regulation of replication origin function. The characteristic initiation timing of specific origins is thought to reflect their chromatin environment or sub-nuclear positioning, however the mechanism remains obscure. Here we show that the yeast Forkhead transcription factors, Fk...
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Sld3/Treslin is an evolutionarily conserved protein essential for activation of DNA helicase Mcm2-7 and replication initiation in all eukaryotes. Nevertheless, it remains elusive how Sld3 is recruited to origins. Here, we have identified the direct physical association of Sld3 with Mcm2 and Mcm6 subunits in vitro, which is significantly enhanced by DDK in vivo. The Sld3-binding domain (SBD) is ...
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FOXM1 (12p13.33) GLI1, doxorubicin, NRAS, fulvestrant, butyric acid, FGF7, CDKN1A, YY1, MSA, vitamin D3, TNFSF11, IL6, CDC2 CDC25B, CENPA, AURKB, CCNA2, CCNF, CENPB, BIRC5, CCNB1, CDKN1A, ESR1, ADAM17, GLB1 Controls progression into S phase; regulates genes required for mitotic entry; liver development. Reduced hepatoblast and cardiomyocyte mitosis, ventricular hypoplasia. Die perinatally. Upre...
متن کاملLimiting replication initiation factors execute the temporal programme of origin firing in budding yeast.
Eukaryotic chromosomes are replicated from multiple origins that initiate throughout the S-phase of the cell cycle. Why all origins do not fire simultaneously at the beginning of S-phase is not known, but two kinase activities, cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK), are continually required throughout the S-phase for all replication initiation events. Here, we show that ...
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The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. This regulation appears to be in the opposite direction from the genetic in...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2017
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.306571.117